Broncos vs. Jaguars predictions: Final score picks for NFL Week 16

The Denver Broncos go into Week 16 looking to defend their 11-game win streak and undefeated home record against the red-hot Jacksonville Jaguars. Coming off a big win over the Green Bay Packers who had come into Denver as favorites despite having a worse record, confidence should be running sky high for this Broncos football team.

There is a scenario where the Broncos can clinch all of the things from the number one seed in the AFC and the AFC West division title. It’s unlikely for all of those to happen, but they can certainly take the division with the win and a Los Angeles Chargers loss on Sunday.

Game Overview

Denver Broncos vs. Jacksonville Jaguars
Sunday, December 21, 2025 at 2:05 P.M. Mile High time
Empower Field at Mile High in Denver, Colorado
ATS Betting Lines: Denver -3.5
Moneyline Odds: Denver -180 / Jacksonville +152
Over/Under: 46.5
Note: All odds courtesy of FanDuel Sportsbook.

Broncos vs Jaguars Score Predictions

Collectively, our Mile High Report staff is predicting a Broncos 31-16 win at home over the Jaguars. Here’s how each of us predicted things would go individually:

Broncos 27, Jaguars 17

Part of me doesn’t want to stop predicting one-score games, but this is a matchup that I feel favors the Broncos in almost every category. Trevor Lawrence has been playing out of his mind, but his worst games have all come against elite defenses. With Bo Nix playing like the best version of himself, I feel like the Broncos will pull away from the Jags in this game at some point. – Tim Lynch

Broncos 31, Jaguars 23

The tests don’t stop for the Broncos. The Jags come in on a heater with 5 wins in a row. They have a strong run game and a quarterback who is on fire. Their defense is exceptionally great at taking the ball away. That being said, they haven’t played a team at the Broncos level yet. I like Denver at home with the altitude and the rabid fans behind them. – Sadaraine

Broncos 41, Jaguars 17

Broncos haven’t lost at home since Week 6 of 2024, they’ve won 11 straight games, and QB Bo Nix is coming off his best career game. Last week, this team just defeated a tough Packers team that came into Mile High hot and feeling good and will do the same against the Jags this Sunday.

The Jags have beat up on the Titans, Jets, and a Colts team after they lost their QB in recent weeks. The Broncos are a different animal and are peaking at the right time.

Bo Nix has back-to-back 4 TD performances(If Geno Smith can do it against the Jags, Bo can), RJ Harvey tops 100 yards from scrimmage, the defense gets multiple turnovers and 5+ sacks of Trevor Lawrence and clinch the AFC West after the Chargers fall to the Cowboys. – Scotty Payne

Broncos 27, Jaguars 20

Two division leaders are going head-to-head in this one. I think it’s going to be a great game. I’ve got a lot of respect for the Jaguars for what they have accomplished this season. Their offense has been scoring a lot of points lately and their defense creates a lot of turnovers. Even so, I’m confident that the Broncos can keep rolling and continue their incredible win streak. I think Bo Nix and the offense continue their success and think the defense makes a few big plays to change the momentum. It’ll be a close game but believe Denver will come away with their thirteenth victory in 2025. – Chris Hart

Broncos 28, Jaguars 10

These are two very similar teams. They feel disrespected and they are exceeding the expectations of the experts. Bo Nix and Trevor Lawerence have remarkably similar statistics except that Lawrence has taken twice as many sacks as Bo. And the Broncos defense has more than twice has many sacks as Jacksonville. That’s the difference. Bo will have time to throw; Trevor will not. The pass rush wins this game. – Mike DeCicco

Broncos 31, Jaguars 7

Streaks always end. It’s just a fact. But not this week. As Scotty mentioned, the Jaguars have been on a run of their own, but against bad teams. The Broncos have put together a run that includes beating a desperate Chiefs, and a Packers team that many believe could (have) been a Super Bowl contender. With a chance to clinch the division, and inch closer to that #1 seed in the AFC, Sean Payton will have the offense ready to go. The defense will get to Trevor Lawrence, PS2 will limit Jakobi Meyers. The Dline will bottle up Travis Etienne. – Adam Malnati

Broncos 31, Jaguars 17

Payton, Nix, and the Broncos are on a mission. They want to win the AFC West. They want the No. 1 seed in the AFC. Any chance of a Michael Dean Perry-esque lagging off the field on third down isn’t going to happen this Sunday. The defense is going to make the day completely miserable and uncomfortable for Lawrence. The Broncos will control the line of scrimmage on both sides of the ball, and the offense will put forth another complete game. And Broncos Country is going to bring the Rocky Mountain Thunder like its old Mile High. – Ian St. Clair

Broncos 34, Jaguars 20

There is too much on the line for this team to come up short. Over the last three months the Broncos have shown up to very occasion and have proven themselves to be an elite team. Their offense is running on all cylinders, the offensive line is getting a boost with Ben Powers returning, and if the defense looks like it did in the second half of last week’s game, then it should be a long night for the Jags. – Ross Allen

What is your score prediction for the Broncos-Jaguars game? Let us know in the comments section below.